Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial

@article{Kasper2010SilexanAO,
  title={Silexan, an orally administered Lavandula oil preparation, is effective in the treatment of ‘subsyndromal’ anxiety disorder: a randomized, double-blind, placebo controlled trial},
  author={Siegfried Kasper and Markus Gastpar and Walter E. Müller and Hans Peter Volz and Hans-J{\"u}rgen M{\"o}ller and Angelika Dienel and S. Schl{\"a}fke},
  journal={International Clinical Psychopharmacology},
  year={2010},
  volume={25},
  pages={277-287}
}
This study was performed to investigate the anxiolytic efficacy of silexan, a new oral lavender oil capsule preparation, in comparison to placebo in primary care. In 27 general and psychiatric practices 221 adults suffering from anxiety disorder not otherwise specified (Diagnostic and Statistical Manual of Mental disorders–IV 300.00 or International Statistical Classification of Diseases and Related Health Problems, Tenth revision F41.9) were randomized to 80 mg/day of a defined, orally… Expand
An orally administered lavandula oil preparation (Silexan) for anxiety disorder and related conditions: an evidence based review
  • S. Kasper
  • Psychology, Medicine
  • International journal of psychiatry in clinical practice
  • 2013
TLDR
Silexan had beneficial effects on typical co-morbidity symptoms of anxiety disorders, for example, disturbed sleep, somatic complaints, or decreased quality of life and was devoid of adverse effects and did not cause drug interactions or withdrawal symptoms at daily doses of 80 or 160 mg. Expand
Lavender oil preparation Silexan is effective in generalized anxiety disorder--a randomized, double-blind comparison to placebo and paroxetine.
TLDR
In GAD Silexan is more efficacious than placebo and showed a pronounced antidepressant effect and improved general mental health and health-related quality of life. Expand
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The study confirms the calming and anxiolytic efficacy of Silexan in patients with anxiety-related restlessness and disturbed sleep. Expand
Silexan in generalized anxiety disorder: investigation of the therapeutic dosage range in a pooled data set
TLDR
Silexan 160 mg/day was superior to placebo for all efficacy outcomes investigated, with responder rates exceeding 60% on the basis of HAMA and Clinical Global Impressions criteria. Expand
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Silexan had beneficial effects on typical concomitant symptoms of anxiety disorders, such as impaired sleep, somatic complaints, co-morbid depression or decreased quality of life, and did not induce any adverse effects at daily doses of 80 or 160 mg. Expand
Efficacy and safety of lavender essential oil (Silexan) capsules among patients suffering from anxiety disorders: A network meta-analysis
TLDR
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Phase II trial on the effects of Silexan in patients with neurasthenia, post-traumatic stress disorder or somatization disorder.
TLDR
The results in this open-label, exploratory trial justify to further investigate Silexan in disorders with accompanying restlessness caused by sub-threshold anxiety. Expand
A case series on the use of lavendula oil capsules in patients suffering from major depressive disorder and symptoms of psychomotor agitation, insomnia and anxiety.
TLDR
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Lavender and dodder combined herbal syrup versus citalopram in major depressive disorder with anxious distress: A double-blind randomized trial.
TLDR
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Efficacy of Silexan in mixed anxiety–depression – A randomized, placebo-controlled trial
TLDR
Compared to placebo, the patients treated with Silexan had a better over-all clinical outcome and showed more pronounced improvements of impaired daily living skills and health related quality of life. Expand
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