Silent synapses in the immature visual cortex: layer-specific developmental regulation.

@article{Rumpel2004SilentSI,
  title={Silent synapses in the immature visual cortex: layer-specific developmental regulation.},
  author={Simon Rumpel and Gunnar Kattenstroth and Kurt Gottmann},
  journal={Journal of neurophysiology},
  year={2004},
  volume={91 2},
  pages={1097-101}
}
Central glutamatergic synapses are thought to initially form as immature, so-called silent synapses showing exclusively N-methyl-d-aspartate receptor-mediated synaptic transmission. Postsynaptic insertion of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors during further development leads to a conversion into functional, mature synapses. Here, we tested the hypothesis that, according to the "inside first-outside last" pattern of neocortical layer formation and synaptogenesis… CONTINUE READING