Silent mutations turn up the volume

  • Asher Mullard
  • Published 2007 in Nature Reviews Molecular Cell Biology

Abstract

Although a silent mutation doesn’t affect the amino-acid sequence of a protein, it can affect protein folding and function, reports an intriguing Science paper. Chava Kimchi-Sarfaty and colleagues examined a silent mutation that is caused by a synonymous single nucleotide polymorphism (SNP) in MDR1, which encodes the protein pump P-gp. Previous results had… (More)
DOI: 10.1038/nrm2102

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