Silent information regulator 3: the Goldilocks of the silencing complex.

@article{Norris2010SilentIR,
  title={Silent information regulator 3: the Goldilocks of the silencing complex.},
  author={Anne Norris and Jef D. Boeke},
  journal={Genes & development},
  year={2010},
  volume={24 2},
  pages={115-22}
}
A recent explosion of work surrounds the interactions between Sir3p (Silent Information Regulator 3) and chromatin. We review here the Sir3p functions related to its role in silencing in Saccharomyces cerevisiae. This unusual protein, which is absolutely required for silencing, is distantly related to the highly conserved replication initiator Orc1p, but is itself phylogenetically limited to "post-genome-duplicated" budding yeasts. Several recent studies revise earlier models for Sir3p action… CONTINUE READING

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