Silent information regulator 1 protects the heart from ischemia/reperfusion.

  title={Silent information regulator 1 protects the heart from ischemia/reperfusion.},
  author={Chiao-Po Hsu and Peiyong Zhai and Takanobu Yamamoto and Yasuhiro Maejima and Shouji Matsushima and Nirmala Hariharan and Dan Shao and Hiromitsu Takagi and Shinichi Oka and Junichi Sadoshima},
  volume={122 21},
BACKGROUND Silent information regulator 1 (Sirt1), a class III histone deacetylase, retards aging and protects the heart from oxidative stress. We here examined whether Sirt1 is protective against myocardial ischemia/reperfusion (I/R). METHODS AND RESULTS Protein and mRNA expression of Sirt1 is significantly reduced by I/R. Cardiac-specific Sirt1(-/-) mice exhibited a significant increase (44±5% versus 15±5%; P=0.01) in the size of myocardial infarction/area at risk. In transgenic mice with… CONTINUE READING
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