Silent genes in bacteria: the previously designated 'cryptic' ilvHI locus of 'Salmonella typhimurium LT2' is active in natural isolates.

@article{Burns1995SilentGI,
  title={Silent genes in bacteria: the previously designated 'cryptic' ilvHI locus of 'Salmonella typhimurium LT2' is active in natural isolates.},
  author={Dennis M. Burns and Michelle Jane Burger and Ifor R. Beacham},
  journal={FEMS microbiology letters},
  year={1995},
  volume={131 2},
  pages={
          167-72
        }
}
Gene ilvG in Escherichia coli K-12 and ilvI in 'Salmonella typhimurium LT2' (S. enterica serotype Typhimurium, strain LT2) are inactive due to frameshift or nonsense mutations, respectively. These inactive genes have been suggested to be part of 'cryptic' genetic systems which are defined as being of long-term regulatory and evolutionary significance. We have shown that the nonsense mutation in ilvI is present only in derivatives of the laboratory strain 'S. typhimurium LT2'. All natural… CONTINUE READING