Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease.

@article{Hulbert2011SilentCI,
  title={Silent cerebral infarcts occur despite regular blood transfusion therapy after first strokes in children with sickle cell disease.},
  author={Monica L Hulbert and Robert C. McKinstry and Joanne Lacey and C J Moran and Julie Ann Panepinto and Alexis A Thompson and Sharada A. Sarnaik and Gerald M. Woods and James F. Casella and Baba P. D. Inusa and Jo Howard and Fenella Jane Kirkham and Kofi A. Anie and Jonathan Mullin and Rebecca N. Ichord and Michael S Noetzel and Yan Yan and Mark Rodeghier and Michael R. DeBaun},
  journal={Blood},
  year={2011},
  volume={117 3},
  pages={772-9}
}
Children with sickle cell disease (SCD) and strokes receive blood transfusion therapy for secondary stroke prevention; despite this, approximately 20% experience second overt strokes. Given this rate of second overt strokes and the clinical significance of silent cerebral infarcts, we tested the hypothesis that silent cerebral infarcts occur among children with SCD being transfused for secondary stroke prevention. A prospective cohort enrolled children with SCD and overt strokes at 7 academic… CONTINUE READING
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