Silencing viruses by RNA interference.

  title={Silencing viruses by RNA interference.},
  author={Florence Colb{\`e}re-Garapin and Bruno Blondel and Aure Saulnier and Isabelle Pelletier and Karine Labadie},
  journal={Microbes and infection},
  volume={7 4},
Post-transcriptional gene silencing (PTGS) makes possible new approaches for studying the various steps of the viral cycle. Plus-strand RNA viruses appear to be attractive targets for small interfering RNAs (siRNAs), as their genome functions as both mRNA and replication template. PTGS creates an alternative to classic reverse genetics for viruses with either negative-strand or double-stranded RNA genomes and for those with a large genome. PTGS allows modification of the expression of a given… CONTINUE READING
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