Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae

  title={Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae},
  author={K. Ono and T. Nakagawa and K. Kojima and M. Matsumoto and Juichi Ito},
  journal={Molecular and Cellular Neuroscience},
  • K. Ono, T. Nakagawa, +2 authors Juichi Ito
  • Published 2009
  • Biology, Medicine
  • Molecular and Cellular Neuroscience
  • The post-natal cochlear mammalian epithelium have no capacity to proliferate in tissue, however, dissociated supporting cells exhibit the ability to divide and trans-differentiate into new hair cells in vitro, with this process found to be correlated with the downregulation of the cyclin-dependent kinase inhibitor p27(kip1). Here we show that knockdown of p27(kip1) with short hairpin RNA-expressing vectors results in the cell-cycle reentry of post-mitotic supporting cells in the post-natal… CONTINUE READING
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