Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae
@article{Ono2009SilencingPR, title={Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae}, author={K. Ono and T. Nakagawa and K. Kojima and M. Matsumoto and Juichi Ito}, journal={Molecular and Cellular Neuroscience}, year={2009}, volume={42}, pages={391-398} }
The post-natal cochlear mammalian epithelium have no capacity to proliferate in tissue, however, dissociated supporting cells exhibit the ability to divide and trans-differentiate into new hair cells in vitro, with this process found to be correlated with the downregulation of the cyclin-dependent kinase inhibitor p27(kip1). Here we show that knockdown of p27(kip1) with short hairpin RNA-expressing vectors results in the cell-cycle reentry of post-mitotic supporting cells in the post-natal… CONTINUE READING
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References
SHOWING 1-10 OF 29 REFERENCES
Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti.
- Biology, Medicine
- Proceedings of the National Academy of Sciences of the United States of America
- 1999
- 360
- Highly Influential
- PDF
Mammalian cochlear supporting cells can divide and trans-differentiate into hair cells
- Biology, Medicine
- Nature
- 2006
- 344
- Highly Influential
- PDF
p27(Kip1) links cell proliferation to morphogenesis in the developing organ of Corti.
- Biology, Medicine
- Development
- 1999
- 517
- Highly Influential
- PDF
Progressive hearing loss in mice lacking the cyclin-dependent kinase inhibitor Ink4d
- Biology, Medicine
- Nature Cell Biology
- 2003
- 179
The retinoblastoma gene pathway regulates the postmitotic state of hair cells of the mouse inner ear
- Biology, Medicine
- Development
- 2005
- 136
- PDF
p19Ink4d and p21Cip1 Collaborate to Maintain the Postmitotic State of Auditory Hair Cells, Their Codeletion Leading to DNA Damage and p53-Mediated Apoptosis
- Biology, Medicine
- The Journal of Neuroscience
- 2007
- 95
- PDF
Alteration in expression of p27 in auditory epithelia and neurons of mice during degeneration
- Biology, Medicine
- Neuroscience Letters
- 2002
- 13
Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells
- Biology, Medicine
- Proceedings of the National Academy of Sciences
- 2008
- 81
- PDF
Atoh1 expression defines activated progenitors and differentiating hair cells during avian hair cell regeneration
- Biology, Medicine
- Developmental dynamics : an official publication of the American Association of Anatomists
- 2007
- 123