Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae

@article{Ono2009SilencingPR,
  title={Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae},
  author={Kazuya Ono and Takayuki Nakagawa and Ken Kojima and Masahiro Matsumoto and Takeshi Kawauchi and Mikio Hoshino and Juichi Ito},
  journal={Molecular and Cellular Neuroscience},
  year={2009},
  volume={42},
  pages={391-398}
}
The post-natal cochlear mammalian epithelium have no capacity to proliferate in tissue, however, dissociated supporting cells exhibit the ability to divide and trans-differentiate into new hair cells in vitro, with this process found to be correlated with the downregulation of the cyclin-dependent kinase inhibitor p27(kip1). Here we show that knockdown of p27(kip1) with short hairpin RNA-expressing vectors results in the cell-cycle reentry of post-mitotic supporting cells in the post-natal… Expand
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