• DOI:10.1016/j.mcn.2009.08.011
Corpus ID: 206831997

Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae

@article{Ono2009SilencingPR,
  title={Silencing p27 reverses post-mitotic state of supporting cells in neonatal mouse cochleae},
  author={K. Ono and T. Nakagawa and K. Kojima and M. Matsumoto and Juichi Ito},
  journal={Molecular and Cellular Neuroscience},
  year={2009},
  volume={42},
  pages={391-398}
}

K. Ono, T. Nakagawa, +2 authors Juichi Ito

Published 2009

Biology, Medicine

Molecular and Cellular Neuroscience

The post-natal cochlear mammalian epithelium have no capacity to proliferate in tissue, however, dissociated supporting cells exhibit the ability to divide and trans-differentiate into new hair cells in vitro, with this process found to be correlated with the downregulation of the cyclin-dependent kinase inhibitor p27(kip1). Here we show that knockdown of p27(kip1) with short hairpin RNA-expressing vectors results in the cell-cycle reentry of post-mitotic supporting cells in the post-natal… CONTINUE READING

View on Elsevier

repository.kulib.kyoto-u.ac.jp

Save to Library

Create Alert

Cite

Launch Research Feed