Silencing of unpaired meiotic chromosomes and altered recombination patterns in an azoospermic carrier of a t(8;13) reciprocal translocation.

@article{Ferguson2008SilencingOU,
  title={Silencing of unpaired meiotic chromosomes and altered recombination patterns in an azoospermic carrier of a t(8;13) reciprocal translocation.},
  author={Kyle A Ferguson and Victor Chow and Sai Ma},
  journal={Human reproduction},
  year={2008},
  volume={23 4},
  pages={988-95}
}
BACKGROUND Male carriers of structural chromosomal abnormalities provide a useful model for studying the effects of impaired synapsis on human meioses and male fertility. METHODS We used immunofluorescent techniques to examine recombination (MLH1), synapsis (SYCP3/SYCP1) and transcriptional inactivation (BRCA1/gammaH2AX/RNA polymerase II) of meiotic chromosomes in an azoospermic carrier of a t(8;13) reciprocal translocation. Two biopsies were performed 1 year apart and on different testes… CONTINUE READING

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Changes in crossover distribution along a quadrivalent in a man carrier of a reciprocal translocation t(11;14).

Biocell : official journal of the Sociedades Latinoamericanas de Microscopia Electronica ... et. al • 2005
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