Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.

@article{Murphy2013SilencingOT,
  title={Silencing of the miR-17~92 cluster family inhibits medulloblastoma progression.},
  author={BertL. Murphy and Susanna Obad and Laure Bihannic and Olivier Ayrault and Fr{\'e}d{\'e}rique Zindy and Sakari Kauppinen and Martine F Roussel},
  journal={Cancer research},
  year={2013},
  volume={73 23},
  pages={
          7068-78
        }
}
Medulloblastoma, originating in the cerebellum, is the most common malignant brain tumor in children. Medulloblastoma consists of four major groups where constitutive activation of the Sonic Hedgehog (SHH) signaling pathway is a hallmark of one group. Mouse and human SHH medulloblastomas exhibit increased expression of microRNAs encoded by the miR-17~92 and miR-106b~25 clusters compared with granule progenitors and postmitotic granule neurons. Here, we assessed the therapeutic potential of 8… CONTINUE READING
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