Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure.

@article{SjblomHalln1999SilencingOT,
  title={Silencing of the Epstein-Barr virus latent membrane protein 1 gene by the Max-Mad1-mSin3A modulator of chromatin structure.},
  author={Anna Sj{\"o}blom-Hall{\'e}n and Weiwen Yang and Ann Jansson and L. Rymo},
  journal={Journal of virology},
  year={1999},
  volume={73 4},
  pages={2983-93}
}
The tumor-associated latent membrane protein 1 (LMP1) gene in the Epstein-Barr virus (EBV) genome is activated by EBV-encoded proteins and cellular factors that are part of general signal transduction pathways. As previously demonstrated, the proximal region of the LMP1 promoter regulatory sequence (LRS) contains a negative cis element with a major role in EBNA2-mediated regulation of LMP1 gene expression in B cells. Here, we show that this silencing activity overlaps with a transcriptional… CONTINUE READING
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