Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1‐DMAP1 complex in female fecundity

@article{Gegner2020SilencingOT,
  title={Silencing of the DNA methyltransferase 1 associated protein 1 (DMAP1) gene in the invasive ladybird Harmonia axyridis implies a role of the DNA methyltransferase 1‐DMAP1 complex in female fecundity},
  author={J. Gegner and T. Gegner and H. Vogel and A. Vilcinskas},
  journal={Insect Molecular Biology},
  year={2020},
  volume={29}
}
The invasive harlequin ladybird Harmonia axyridis is a textbook example of polymorphism and polyphenism as the temperature during egg development determines the frequency of melanic morphs and the number and size of black spots in nonmelanic morphs. Recent concepts in evolutionary biology suggest that epigenetic mechanisms can translate environmental stimuli into heritable phenotypic changes. To investigate whether epigenetic mechanisms influence the penetrance and expressivity of colour morphs… Expand
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References

SHOWING 1-10 OF 60 REFERENCES
DNA methyltransferases have an essential role in female fecundity in brown planthopper, Nilaparvata lugens.
TLDR
It is indicated that a complete DNA methylation toolkit exists in the brown planthopper, Nilaparvata lugens, a destructive pest in rice production and Silencing NLU-Dnmt1 and Nlu-DNmt3 in gravid brachypterous female adults led to fewer offspring, suggesting that DNA methylations regulates female fecundity in insects. Expand
Dnmt1 is essential for egg production and embryo viability in the large milkweed bug, Oncopeltus fasciatus
TLDR
This study provides direct experimental evidence for a functional role of Dnmt1 in egg production and embryo viability and uncovers a trivial role, if any, for DNA methylation in control of gene expression in O. fasciatus. Expand
Developmental DNA methyltransferase expression in the fire ant Solenopsis invicta
TLDR
The hypothesis that extensive patterning of DNA methylation occurs during gametogenesis and embryogenesis in the insect order Hymenoptera is supported. Expand
Dnmt1 has an essential function despite the absence of CpG DNA methylation in the red flour beetle Tribolium castaneum
TLDR
It is shown that Dnmt1 plays an essential role in T. castaneum embryos and that its downregulation leads to an early developmental arrest, which strongly suggests an alternative role of this protein. Expand
Insulin-like peptides and DNA/tRNA methyltransferases are involved in the nutritional regulation of female reproduction in Nilaparvata lugens (Stål).
TLDR
It is inferred that amino acids act on ILPs and Dnmts to regulate vitellogenesis and oocyte maturation in N. lugens, and RNA interference-mediated depletion of NlILP2 or Nl ILP4 dramatically decreased the expression levels of NLDnmt1 and NlDnMT2, and resulted in severely impaired ovary growth as well as the substantial reduction of fecundity. Expand
DNA Methyltransferase 1-associated Protein (DMAP1) Is a Co-repressor That Stimulates DNA Methylation Globally and Locally at Sites of Double Strand Break Repair*
TLDR
DMAP1 is a potent activator of DNMT1 methylation in vitro, suggesting that DMAP 1 is a co-repressor that supports the maintenance and de novo action ofDNMT1. Expand
The Impact of Parasites on Host Insect Epigenetics
TLDR
Research on epigenetic regulation at the molecular, cellular, tissue, organ and organism levels in insects represents an emerging field to understand the regulation of complex parameters such as longevity, fecundity and reproduction. Expand
Epigenetic Mechanisms Are Involved in Sex-Specific Trans-Generational Immune Priming in the Lepidopteran Model Host Manduca sexta
TLDR
Investigating sex-specific TGIP in insects found that feeding larvae with non-pathogenic Escherichia coli or the entomopathogen Serratia entomophila triggered immune responses in the infected host associated with shifts in both DNA methylation and histone acetylation. Expand
DNA methylation in insects: on the brink of the epigenomic era
TLDR
It is suggested that insects are particularly amenable to advancing the understanding of the biological functions of DNA methylation, because insects are evolutionarily diverse, display several lineage‐specific losses ofDNA methylation and possess tractable patterns of DNAmethylation in moderately sized genomes. Expand
The model beetle Tribolium castaneum can be used as an early warning system for transgenerational epigenetic side effects caused by pharmaceuticals.
TLDR
It is confirmed that Tribolium castaneum is potentially useful as an alternative model to screen for the epigenetic effect of drugs, and provides a valuable early warning system for transgenerational epigenetic risk factors that are difficult to detect in mammals. Expand
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