Silencing of the CHM gene alters phagocytic and secretory pathways in the retinal pigment epithelium.

@article{Gordiyenko2010SilencingOT,
  title={Silencing of the CHM gene alters phagocytic and secretory pathways in the retinal pigment epithelium.},
  author={Nataliya V Gordiyenko and Robert N Fariss and Connie Zhi and Ian M MacDonald},
  journal={Investigative ophthalmology & visual science},
  year={2010},
  volume={51 2},
  pages={1143-50}
}
PURPOSE Choroideremia (CHM) is an X-linked progressive degeneration of the retinal pigment epithelium (RPE), photoreceptors, and choroid caused by mutations in the CHM gene, which encodes Rab escort-protein-1 (REP-1). REP-1 enables posttranslational isoprenyl modification of Rab GTPases, proteins that control vesicle formation, movement, docking, and fusion. The aim of this study was to determine the effect of REP-1 depletion on vesicular trafficking in phagocytic and secretory pathways of… CONTINUE READING
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