Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH.

@article{Bedi2012SilencingOP,
  title={Silencing of parathyroid hormone (PTH) receptor 1 in T cells blunts the bone anabolic activity of PTH.},
  author={Brahmchetna Bedi and Jau-Yi Li and Hesham Tawfeek and Ki Hyun Baek and Jonathan Adams and Sameera S. Vangara and Ming-Kang Chang and Michaela Kneissel and M Neale Weitzmann and Roberto Pacifici},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2012},
  volume={109 12},
  pages={E725-33}
}
Intermittent parathyroid hormone (iPTH) treatment stimulates T-cell production of the osteogenic Wnt ligand Wnt10b, a factor required for iPTH to activate Wnt signaling in osteoblasts and stimulate bone formation. However, it is unknown whether iPTH induces Wnt10b production and bone anabolism through direct activation of the parathyroid hormone (PTH)/PTH-related protein receptor (PPR) in T cells. Here, we show that conditional silencing of PPR in T cells blunts the capacity of iPTH to induce T… CONTINUE READING
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