Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine.

@article{Tang2005SilencingOP,
  title={Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine.},
  author={Dale D Tang and Ying Bai and Susan J Gunst},
  journal={The Biochemical journal},
  year={2005},
  volume={388 Pt 3},
  pages={773-83}
}
Vimentin intermediate filaments undergo spatial reorganization in endothelial cells and fibroblasts in response to stimulation with platelet-derived growth factor and epidermal growth factor. In the present study, the vimentin network exhibited a curved filamentous structure in unstimulated smooth muscle cells. Vimentin filaments became straight and were arranged along the long axis of cells upon stimulation with 5-hydroxytryptamine (5-HT; serotonin). Stimulation of smooth muscle cells with 5… CONTINUE READING

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p21-activated protein kinase 1 (PAK1) is required for vimentin phosphorylation at Ser-56 during stimulation of smooth muscle tissues

  • D. D. Tang, P. Tao, Y. Bai
  • FASEB J
  • 2004

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