Silencing of microRNA families by seed-targeting tiny LNAs

  title={Silencing of microRNA families by seed-targeting tiny LNAs},
  author={Susanna Obad and Camila O. Dos Santos and Andreas Petri and Markus Heidenblad and Oliver Jay Broom and Cristian I. Ruse and Cexiong Fu and Morten Lindow and Jan Stenvang and Ellen Marie Straarup and Henrik Frydenlund Hansen and Troels Koch and Darryl J. Pappin and Gregory J Hannon and Sakari Kauppinen},
  journal={Nature Genetics},
The challenge of understanding the widespread biological roles of animal microRNAs (miRNAs) has prompted the development of genetic and functional genomics technologies for miRNA loss-of-function studies. However, tools for exploring the functions of entire miRNA families are still limited. We developed a method that enables antagonism of miRNA function using seed-targeting 8-mer locked nucleic acid (LNA) oligonucleotides, termed tiny LNAs. Transfection of tiny LNAs into cells resulted in… CONTINUE READING
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