Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

@article{Zheng2015SilencingOM,
  title={Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice},
  author={Dong Zheng and Jian Ma and Yong Yu and Minghui Li and Rui Ni and Grace Wang and Ruizhen Rachel Chen and Jianmin Li and Guo-Chang Fan and James C. Lacefield and Tianqing Peng},
  journal={Diabetologia},
  year={2015},
  volume={58},
  pages={1949-1958}
}
MicroRNAs (miRs) have been suggested as potential therapeutic targets for heart diseases. Inhibition of miR-195 prevents apoptosis in cardiomyocytes stimulated with palmitate and transgenic overexpression of miR-195 induces cardiac hypertrophy and heart failure. We investigated whether silencing of miR-195 reduces diabetic cardiomyopathy in a mouse model of streptozotocin (STZ)-induced type 1 diabetes. Type 1 diabetes was induced in C57BL/6 mice (male, 2 months old) by injections of STZ. MiR… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 16 extracted citations

Regulating microRNA expression: at the heart of diabetes mellitus and the mitochondrion.

American journal of physiology. Heart and circulatory physiology • 2018
View 2 Excerpts

Exosomes in Cardiovascular Diseases

Xiao Sanda
Advances in Experimental Medicine and Biology • 2017

MicroRNA as a Therapeutic Target in Cardiac Remodeling

BioMed research international • 2017
View 1 Excerpt

References

Publications referenced by this paper.
Showing 1-10 of 48 references

Diabetic cardiomyopathy revisited.

Circulation • 2007
View 4 Excerpts
Highly Influenced

Role of miR-195 in aortic aneurysmal disease.

Circulation research • 2014
View 1 Excerpt

Similar Papers

Loading similar papers…