Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice

  title={Silencing of miR-195 reduces diabetic cardiomyopathy in C57BL/6 mice},
  author={Dong Zheng and Jian Ma and Yong Yu and Minghui Li and Rui Ni and Grace Wang and Ruizhen Rachel Chen and Jianmin Li and Guo-Chang Fan and James C. Lacefield and Tianqing Peng},
MicroRNAs (miRs) have been suggested as potential therapeutic targets for heart diseases. Inhibition of miR-195 prevents apoptosis in cardiomyocytes stimulated with palmitate and transgenic overexpression of miR-195 induces cardiac hypertrophy and heart failure. We investigated whether silencing of miR-195 reduces diabetic cardiomyopathy in a mouse model of streptozotocin (STZ)-induced type 1 diabetes. Type 1 diabetes was induced in C57BL/6 mice (male, 2 months old) by injections of STZ. MiR… CONTINUE READING


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