Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3

@article{Tringali2009SilencingOM,
  title={Silencing of membrane-associated sialidase Neu3 diminishes apoptosis resistance and triggers megakaryocytic differentiation of chronic myeloid leukemic cells K562 through the increase of ganglioside GM3},
  author={Cristina Tringali and Barbara Lupo and F Cirillo and Nadia Papini and Luigi Anastasia and Giuseppe Lamorte and Paolo Colombi and Roberto Bresciani and Eugenio Monti and Guido Tettamanti and B Venerando},
  journal={Cell Death and Differentiation},
  year={2009},
  volume={16},
  pages={164-174}
}
In chronic myeloid leukemia K562 cells, differentiation is also blocked because of low levels of ganglioside GM3, derived by the high expression of sialidase Neu3 active on GM3. In this article, we studied the effects of Neu3 silencing (40–70% and 63–93% decrease in protein content and activity, respectively) in these cells. The effects were as follows: (a) gangliosides GM3, GM1, and sialosylnorhexaosylceramide increased markedly; (b) cell growth and [3H]thymidine incorporation diminished… CONTINUE READING
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