Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi.

@article{Sapru2006SilencingOH,
  title={Silencing of human alpha-synuclein in vitro and in rat brain using lentiviral-mediated RNAi.},
  author={Mohan K Sapru and Jonathan W Yates and Shea Hogan and Lixin Jiang and Jeremy Halter and Martha C. Bohn},
  journal={Experimental neurology},
  year={2006},
  volume={198 2},
  pages={382-90}
}
Human alpha-synuclein overexpression and its toxic accumulation in neurons or glia are known to play key roles in the pathogenesis of Parkinson's disease and other related neurodegenerative synucleinopathies. Several single point mutations in the alpha-synuclein gene, as well as gene duplication and triplication, have been linked to familial Parkinson's disease. Moreover, genetic variability of the alpha-synuclein gene promoter is associated with idiopathic Parkinson's disease. Silencing of the… CONTINUE READING