Silencing of germline-expressed genes by DNA elimination in somatic cells.

  title={Silencing of germline-expressed genes by DNA elimination in somatic cells.},
  author={Jianbin Wang and Makedonka Dautova Mitreva and Matthew Berriman and Alicia Thorne and Vincent J. Magrini and Georgios Koutsovoulos and Sujai Kumar and Mark L. Blaxter and Richard E Davis},
  journal={Developmental cell},
  volume={23 5},
Chromatin diminution is the programmed elimination of specific DNA sequences during development. It occurs in diverse species, but the function(s) of diminution and the specificity of sequence loss remain largely unknown. Diminution in the nematode Ascaris suum occurs during early embryonic cleavages and leads to the loss of germline genome sequences and the formation of a distinct genome in somatic cells. We found that ∼43 Mb (∼13%) of genome sequence is eliminated in A. suum somatic cells… CONTINUE READING
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