Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock.

@article{Matsuda2007SilencingOC,
  title={Silencing of caspase-8 and caspase-3 by RNA interference prevents vascular endothelial cell injury in mice with endotoxic shock.},
  author={Naoyuki Matsuda and Yasuo Takano and Shun-ichiro Kageyama and Noboru Hatakeyama and Kiyoshi Shakunaga and Isao Kitajima and Mitsuaki Yamazaki and Yuichi Hattori},
  journal={Cardiovascular research},
  year={2007},
  volume={76 1},
  pages={
          132-40
        }
}
OBJECTIVES Septic shock and sequential multiple organ failure remain the cause of death in septic patients. Vascular endothelial cell apoptosis may play a role in the pathogenesis of the septic syndrome. Caspase-8 is presumed to be the apex of the death receptor-mediated apoptosis pathway, whereas caspase-3 belongs to the "effector" protease in the apoptosis cascade. Synthetic small interfering RNAs (siRNAs) specifically suppress gene expression by RNA interference. Therefore, we evaluated the… CONTINUE READING
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