Silencing of Transforming Growth Factor-B 1 In situ by RNA Interference for Breast Cancer : Implications for Proliferation andMigration In vitro andMetastasis In vivo

Purpose:Overexpressionof transforming growth factor (TGF)-hhas been implicated inpromoting immune suppression, tumor angiogenesis, tumor cellmigration, and invasion inmany cancers, including carcinoma of the breast.Thus, targeted down-regulation ofTGF-h1expression in breast cancer in situ and determination of its implications would provide new treatment… CONTINUE READING