Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity

@article{Shen2004SilencingOS,
  title={Silencing of SOCS1 enhances antigen presentation by dendritic cells and antigen-specific anti-tumor immunity},
  author={Lei Shen and Kevin Evel-Kabler and Randy Strube and Si-Yi Chen},
  journal={Nature Biotechnology},
  year={2004},
  volume={22},
  pages={1546-1553}
}
Tumor vaccines represent a promising therapeutic approach, but thus far have achieved only limited success in the clinic. The major challenge is to find a means of overcoming inhibitory immune regulatory mechanisms and eliciting effective T-cell responses to antigens preferentially expressed by tumor cells. Here we show that the stimulatory capacity of… CONTINUE READING