Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells.

@article{Choudhury2010SilencingOR,
  title={Silencing of ROR1 and FMOD with siRNA results in apoptosis of CLL cells.},
  author={Aniruddha Choudhury and Katja Derkow and Amir Hossein Daneshmanesh and Eva Mikaelsson and Shahryar Kiaii and Parviz Kokhaei and Anders {\"O}sterborg and H{\aa}kan Mellstedt},
  journal={British journal of haematology},
  year={2010},
  volume={151 4},
  pages={
          327-35
        }
}
We have previously demonstrated that ROR1 and FMOD (fibromodulin) are two genes upregulated in chronic lymphocytic leukaemia (CLL) cells compared to normal blood B cells. In this study, siRNAs were used to specifically silence ROR1 and FMOD expression in CLL cells, healthy B cells and human fibroblast cell lines. siRNA treatment induced a specific reduction (75-95%) in FMOD and ROR1 mRNA. Western blot analysis with specific antibodies for FMOD and ROR1 demonstrated that the proteins were… CONTINUE READING
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