Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Krüppel-type zinc finger factor.

@article{Moosmann1997SilencingOR,
  title={Silencing of RNA polymerases II and III-dependent transcription by the KRAB protein domain of KOX1, a Kr{\"u}ppel-type zinc finger factor.},
  author={Peter R. Moosmann and Oleg G. Georgiev and Hans J{\"u}rgen Thiesen and Michael Hagmann and Walter Schaffner},
  journal={Biological chemistry},
  year={1997},
  volume={378 7},
  pages={
          669-77
        }
}
The so-called KRAB domain, which is present in about one third of the vertebrate Kruppel-type zinc finger factors, has previously been shown to inhibit transcription in cis when tethered to promoter regions. Here we analyze this effect with fusions of the KRAB domain derived from KOX1/ZNF10 zinc finger protein to the heterologous DNA binding domains of both LexA and GAL4 factors. In transfected human cells, repression of reporter gene transcription is observed not only from proximal promoter… CONTINUE READING

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