Silencing of HIF-1α suppresses tumorigenicity of renal cell carcinoma through induction of apoptosis

Abstract

Hypoxia-inducible factor-1α (HIF-1α) is a main responder to intracellular hypoxia and is overexpressed in many human cancers, including renal cell carcinoma (RCC). To better understanding of the role of HIF-1α in the tumorigenicity of RCC, we used short-hairpin RNA (shRNA) interference to inhibit HIF-1α expression in the human renal cancer cell line, Caki-1… (More)
DOI: 10.1038/cgt.2009.66

8 Figures and Tables

Topics

  • Presentations referencing similar topics