Silencing of FOXRED1 in C57b1/6 mice does not generate an appropriate animal model of Leigh syndrome

@article{Finsterer2018SilencingOF,
  title={Silencing of FOXRED1 in C57b1/6 mice does not generate an appropriate animal model of Leigh syndrome},
  author={Josef Finsterer},
  journal={Metabolic Brain Disease},
  year={2018},
  volume={34},
  pages={1-2}
}
With interest we read the article by Salama et al. who pretended to have developed a mouse model of Leigh syndrome by blocking the FOXRED1 gene with small interfering RNAs (siRNA) using C57b1/6 mice (Salama et al. 2018). Neuropathological studies showed degeneration of the corpus striatum, similar to Leigh syndrome, why these animals were regarded as a putative animal model for Leigh syndrome (Salama et al. 2018). We have the following comments and concerns. Pathognomonic for Leigh syndrome are… CONTINUE READING