Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis.

@article{Gmez2016SilencingOD,
  title={Silencing of Dok-7 in Adult Rat Muscle Increases Susceptibility to Passive Transfer Myasthenia Gravis.},
  author={Alejandro Mosquera G{\'o}mez and Jo Stevens and Marina Man{\'e}-Damas and Peter Molenaar and Hans J Q Duimel and Fons K C P Verheyen and Judith Cossins and David Beeson and Marc H. de Baets and Mario Losen and Pilar Mart{\'i}nez-Mart{\'i}nez},
  journal={The American journal of pathology},
  year={2016},
  volume={186 10},
  pages={2559-68}
}
Myasthenia gravis (MG) is an autoimmune disease mediated by autoantibodies that target proteins at the neuromuscular junction, primarily the acetylcholine receptor (AChR) and the muscle-specific kinase. Because downstream of kinase 7 (Dok-7) is essential for the full activation of muscle-specific kinase and consequently for dense clustering of AChRs, we… CONTINUE READING