Silencing of DUSP6 gene by RNAi-mediation inhibits proliferation and growth in MDA-MB-231 breast cancer cells: an in vitro study.

@article{Song2015SilencingOD,
  title={Silencing of DUSP6 gene by RNAi-mediation inhibits proliferation and growth in MDA-MB-231 breast cancer cells: an in vitro study.},
  author={Hongming Song and Chenyang Wu and Chuankui Wei and Dengfeng Li and Kaiyao Hua and Jialu Song and Hui Xu and Lei Chen and Lin Fang},
  journal={International journal of clinical and experimental medicine},
  year={2015},
  volume={8 7},
  pages={10481-90}
}
BACKGROUND Dual-specificity phosphatase 6 (DUSP6) is a negative feedback mechanism of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), that is associated with cellular proliferation and differentiation. It has been reported that the expression of DUSP6 in different types of breast cancer is diverse and therefore it has… CONTINUE READING