Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinoma

@inproceedings{Zhao2013SilencingOB,
  title={Silencing of B7-H3 increases gemcitabine sensitivity by promoting apoptosis in pancreatic carcinoma},
  author={Xin Zhao and Guang-bo Zhang and W J Gan and Feng Xiong and Zhi Li and Hua Zhao and Dong-ming Zhu and Bin Zhang and Xueguang Zhang and De-chun Li},
  booktitle={Oncology letters},
  year={2013}
}
In numerous types of cancer, the expression of a novel member of the B7 ligand family, the B7-H3 immunoregulatory protein, has been correlated with a poor prognosis. In the present study, we investigated the role of B7-H3 in chemoresistance in pancreatic carcinoma. Silencing of B7-H3, through lentivirus-mediated delivery of stable short hairpin RNA, was observed to increase the sensitivity of the human pancreatic carcinoma cell line Patu8988 to gemcitabine as a result of enhanced drug-induced… CONTINUE READING