Silencing microRNA by interfering nanoparticles in mice

  title={Silencing microRNA by interfering nanoparticles in mice},
  author={Jie Su and Huricha Baigude and Joshua Mccarroll and Tariq M Rana},
  booktitle={Nucleic acids research},
MicroRNAs (miRNAs) are small endogenous non-coding RNAs that regulate post-transcriptional gene expression and are important in many biological processes. Disease-associated miRNAs have been shown to become potential targets for therapeutic intervention. Functions of miRNAs can be inhibited by using antisense oligonucleotides, called anti-miRs, complimentary to the miRNA sequences. Here, we show that systemic delivery of a chemically stabilized anti-miR-122 complexed with interfering… CONTINUE READING
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