Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse

@inproceedings{Bai2016SilencingMP,
  title={Silencing microRNA-143 protects the integrity of the blood-brain barrier: implications for methamphetamine abuse},
  author={Ying Bai and Yuan Zhang and Jun Hong Hua and Xiangyu Yang and Xiaotian Zhang and Ming Duan and Xinjian Zhu and Wenhui Huang and Jie Chao and Rongbin Zhou and Gang Hu and Honghong Yao},
  booktitle={Scientific reports},
  year={2016}
}
MicroRNA-143 (miR-143) plays a critical role in various cellular processes; however, the role of miR-143 in the maintenance of blood-brain barrier (BBB) integrity remains poorly defined. Silencing miR-143 in a genetic animal model or via an anti-miR-143 lentivirus prevented the BBB damage induced by methamphetamine. miR-143, which targets p53 unregulated modulator of apoptosis (PUMA), increased the permeability of human brain endothelial cells and concomitantly decreased the expression of tight… CONTINUE READING

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