Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells

@article{Iwamaru2007SilencingMT,
  title={Silencing mammalian target of rapamycin signaling by small interfering RNA enhances rapamycin-induced autophagy in malignant glioma cells},
  author={Arifumi Iwamaru and Yasuko Kondo and Eiji Iwado and Hiroshi Aoki and Keishi Fujiwara and Tomohisa Yokoyama and Gordon B. Mills and Seiji Kondo},
  journal={Oncogene},
  year={2007},
  volume={26},
  pages={1840-1851}
}
The mammalian target of rapamycin (mTOR) plays a central role in regulating the proliferation of malignant glioma cells, and mTOR-specific inhibitors such as rapamycin analogs are considered as promising therapy for malignant gliomas. However, the efficacy of mTOR inhibitors alone in the treatment of patients with malignant gliomas is only modest, potentially because these agents rather than acting as mTOR kinase inhibitors instead interfere with the function of only mTOR/raptor (regulatory… CONTINUE READING

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