Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells.

@article{Liu2012SilencingGE,
  title={Silencing glypican-3 expression induces apoptosis in human hepatocellular carcinoma cells.},
  author={Shiyuan Liu and Yumin Li and Wei Chen and Pengfei Zheng and Tao Liu and Wenting He and Junqiang Zhang and Xiangting Zeng},
  journal={Biochemical and biophysical research communications},
  year={2012},
  volume={419 4},
  pages={656-61}
}
Hepatocellular carcinoma (HCC) is one of the most common internal malignant tumors. Glypican-3 (GPC3) is involved in the biological and molecular events in the tumorigenesis of HCC. We used RNA interference to evaluate the molecular effects of GPC3 suppression at the translational level and demonstrated for the first time that GPC3 silencing results in a significant elevation of the Bax/Bcl-2 ratio, the release of cytochrome c from mitochondria and the activation of caspase-3. The results… CONTINUE READING