Silencing endothelin-3 expression attenuates the malignant behaviors of human melanoma cells by regulating SPARC levels

Abstract

Endothelin-3 (ET-3) is aberrantly expressed in both metastatic melanoma tissues and cultured melanoma cells. Our previous work showed that ET-3 could promote survival of metastatic melanoma cells via its altered expression. In this study, we investigated the mechanisms responsible for these gene-induced phenotypes in melanoma cells. An ET-3 gene sequence… (More)
DOI: 10.1007/s11596-013-1162-3

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