Silencing dopamine D3‐receptors in the nucleus accumbens shell in vivo induces changes in cocaine‐induced hyperlocomotion

@article{Bahi2005SilencingDD,
  title={Silencing dopamine D3‐receptors in the nucleus accumbens shell in vivo induces changes in cocaine‐induced hyperlocomotion},
  author={Amine Bahi and Fr{\'e}d{\'e}ric Boyer and Gaelle Bussard and J. L. Dreyer},
  journal={European Journal of Neuroscience},
  year={2005},
  volume={21}
}
The dopamine D3 receptor (D3R) is an important pharmacotherapeutic target for its potential role in psychiatric disorders and drug dependence. To further explore its function in rats, a regulatable lentivirus, Lenti‐D3, holding the rat D3R cDNA, has been constructed as well as three nonregulatable lentiviruses, Lenti‐D3‐siRNA1, Lenti‐D3‐siRNA2 and Lenti‐D3‐siRNA3, expressing small hairpin RNAs, aimed at silencing D3R expression and specifically targeted against different regions of the D3R mRNA… 
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Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens
TLDR
Selective D3R antagonism potentiates the behavioral-stimulant effects of cocaine in mice, an effect that is in direct opposition to that produced by selective D2R antagonisms or nonselective D2-like receptor antagonists, likely by facilitating D1-mediated excitation in the nucleus accumbens.
The role of gamma‐synuclein in cocaine‐induced behaviour in rats
TLDR
Surprisingly, coinjection lentiviruses expressing DAT and γ‐synuclein leading to overexpression of both proteins in the NAc resulted in a strong increase in cocaine‐induced rat locomotor activity, which was abolished upon locally silencing these genes, suggesting a synergetic role of bothprotein.
Selective D2 and D3 receptor antagonists oppositely modulate cocaine responses in mice via distinct postsynaptic mechanisms in nucleus accumbens
TLDR
It is demonstrated that selective D3R antagonism potentiates the behavioral-stimulant effects of cocaine in mice, an effect that is in direct opposition to that produced by selective D2R antagonISM or nonselective D2-like receptor antagonists, and is likely mediated by facilitating D1-mediated excitation in the nucleus accumbens.
Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity
TLDR
It is demonstrated that presynaptic D2R can be depleted from specific neuronal populations and implicates nigrostriatal D1R in different behavioral responses to psychotropic drugs.
Alpha‐synuclein in the nucleus accumbens induces changes in cocaine behaviour in rats
TLDR
Overexpression of α‐synuclein in the NAcc induced a 45% increase in locomotor activity and a 1.9‐fold increase of cocaine SA, which could be abolished when the same animal was fed doxycycline, and local inhibition ofα‐syn DNA resulted in significant hypolocomotion activity andA decrease in SA.
Lentiviral vector-mediated dopamine d3 receptor modulation in the rat brain impairs alcohol intake and ethanol-induced conditioned place preference.
TLDR
The results support the notion that the D3R plays an important role in alcohol reward in rats and suggest that a key threshold range of D2R levels is associated with impaired alcohol consumption, and demonstrate that theD3R is an essential component of the molecular pathways underlying the reinforcing properties of alcohol.
Role of accumbens BDNF and TrkB in cocaine-induced psychomotor sensitization, conditioned-place preference, and reinstatement in rats
TLDR
These results demonstrate the crucial function of BDNF—through its receptor TrkB—in the enhancement of locomotor activity, sensitization, conditioned-place preference, CPP-reinstatement, and rewarding effects of cocaine in the mesolimbic dopaminergic pathway.
Silencing urokinase in the ventral tegmental area in vivo induces changes in cocaine‐induced hyperlocomotion
TLDR
Cocaine‐induced behavioural changes, associated with uPA expression, could be suppressed in the presence of doxycycline or uPA‐specific siRNAs expressing lentiviruses, which strongly support the major role of urokinase in cocaine‐mediated plasticity changes.
Dopamine transporter (DAT) knockdown in the nucleus accumbens improves anxiety- and depression-related behaviors in adult mice
Mediating effect of dopamine D3 receptors on Jak2 and GABAAalpha1 expression in mouse brains induced by cocaine.
TLDR
GABAAalpha1 and Jak2 may be involved in chronic cocaine induced neuroadaptations and D3 dopamine receptors play an important role in the expression of these genes.
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