Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol

@article{Mao2007SilencingAC,
  title={Silencing a cotton bollworm P450 monooxygenase gene by plant-mediated RNAi impairs larval tolerance of gossypol},
  author={Ying-Bo Mao and Wen-juan Cai and Jia-Wei Wang and Gao-Jie Hong and Xingxiang Tao and Ling-jian Wang and Yong-Ping Huang and Xiaoya Chen},
  journal={Nature Biotechnology},
  year={2007},
  volume={25},
  pages={1307-1313}
}
We identify a cytochrome P450 gene (CYP6AE14) from cotton bollworm (Helicoverpa armigera), which permits this herbivore to tolerate otherwise inhibitory concentrations of the cotton metabolite, gossypol. CYP6AE14 is highly expressed in the midgut and its expression correlates with larval growth when gossypol is included in the diet. When larvae are fed plant material expressing double-stranded RNA (dsRNA) specific to CYP6AE14, levels of this transcript in the midgut decrease and larval growth… CONTINUE READING
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