Silencing UDP-glucose pyrophosphorylase gene in Phaeodactylum tricornutum affects carbon allocation.

@article{Zhu2016SilencingUP,
  title={Silencing UDP-glucose pyrophosphorylase gene in Phaeodactylum tricornutum affects carbon allocation.},
  author={Bao-Hua Zhu and Hong-Ping Shi and Guan-pin Yang and Na-Na Lv and Miao Yang and Ke-Hou Pan},
  journal={New biotechnology},
  year={2016},
  volume={33 1},
  pages={237-44}
}
The effects of the suppression of UDP-glucose pyrophosphorylase (UGPase) on chrysolaminaran biosynthesis and carbon allocation were investigated in Phaeodactylum tricornutum. The 69% decrease in UGPase activity was accompanied by a 4.89 fold reduction in Ugp transcript abundance. Inactivation of UGPase in P. tricornutum led to a significant decrease in chrysolaminaran content and an increase in lipid synthesis. These findings suggest that UGPase is a rate-limiting enzyme and may play an… CONTINUE READING

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