Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells

  title={Silencing TRPM7 mimics the effects of magnesium deficiency in human microvascular endothelial cells},
  author={Erika Baldoli and Jeanette A.M. Maier},
Evidence has accumulated to suggest that magnesium might play a role in controlling angiogenesis. Since microvascular endothelial cells are protagonists in this process, we investigated the behavior of these cells cultured in low extracellular magnesium or silenced for its transporter Transient Receptor Potential Melastatin (TRPM)7, essential for cellular magnesium homeostasis. In particular, we focused on some crucial steps of the angiogenic process, i.e. proliferation, migration, protease… 

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