Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function

@inproceedings{Callander2012SilencingRI,
  title={Silencing Relaxin-3 in Nucleus Incertus of Adult Rodents: A Viral Vector-based Approach to Investigate Neuropeptide Function},
  author={Gabrielle E. Callander and Sherie Ma and Despina Electra Ganella and Verena C. Wimmer and Andrew L Gundlach and WilliamE. G. Thomas and Ross A D Bathgate},
  booktitle={PloS one},
  year={2012}
}
Relaxin-3, the most recently identified member of the relaxin peptide family, is produced by GABAergic projection neurons in the nucleus incertus (NI), in the pontine periventricular gray. Previous studies suggest relaxin-3 is a modulator of stress responses, metabolism, arousal and behavioural activation. Knockout mice and peptide infusions in vivo have significantly contributed to understanding the function of this conserved neuropeptide. Yet, a definitive role remains elusive due to… CONTINUE READING

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