Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.

@article{Zhang2009SilencingPC,
  title={Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.},
  author={Bin Zhang and Yun Xiu Bai and Hang Ma and Feng Feng and Rui Jin and Zhi Wang and Jian Lin and Shi Peng Sun and Pingxun Yang and Xiao Xiong Wang and Pei Tang Huang and Cui Huang and Ying Peng and Yang Chao Chen and Hsiang-fu Kung and Jun Jian Huang},
  journal={Cancer research},
  year={2009},
  volume={69 1},
  pages={
          75-83
        }
}

• Bin Zhang, Yun Xiu Bai, +13 authors Jun Jian Huang
• Published in Cancer research 2009
• DOI:10.1158/0008-5472.CAN-08-1393

The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed in most human cancers in which it counteracts telomere shortening-induced senescence to confer cancer cell immortalization. However, the role of PinX1 in telomere regulation, as well as in cancer, is still poorly understood. In this study, we showed that the PinX1 protein is constitutively expressed in… CONTINUE READING

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