Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.

@article{Zhang2009SilencingPC,
  title={Silencing PinX1 compromises telomere length maintenance as well as tumorigenicity in telomerase-positive human cancer cells.},
  author={B. Zhang and Y. Bai and Hang Ma and F. Feng and Rui Jin and Z. Wang and J. Lin and S. P. Sun and Pingxun Yang and X. X. Wang and P. Huang and C. Huang and Ying Peng and Y. Chen and Hsiang-fu Kung and J. Huang},
  journal={Cancer research},
  year={2009},
  volume={69 1},
  pages={
          75-83
        }
}
  • B. Zhang, Y. Bai, +13 authors J. Huang
  • Published 2009
  • Biology, Medicine
  • Cancer research
  • The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed in most human cancers in which it counteracts telomere shortening-induced senescence to confer cancer cell immortalization. However, the role of PinX1 in telomere regulation, as well as in cancer, is still poorly understood. In this study, we showed that the PinX1 protein is constitutively expressed in… CONTINUE READING
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