Corpus ID: 21572741

Silencing PinX 1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer Cells

@inproceedings{Zhang2008SilencingP1,
  title={Silencing PinX 1 Compromises Telomere Length Maintenance As Well As Tumorigenicity in Telomerase-Positive Human Cancer Cells},
  author={B. Zhang and Y. Bai and Hang Ma and F. Feng and Rui Jin and Z. Wang and Jian Lin and S. P. Sun and Pingxun Yang and X. X. Wang and P. Huang and C. Huang and Y. Peng and Y. Chen and H. Kung and J. Huang},
  year={2008}
}
  • B. Zhang, Y. Bai, +13 authors J. Huang
  • Published 2008
  • The nucleolar protein PinX1 has been proposed to be a putative tumor suppressor due to its binding to and inhibition of the catalytic activity of telomerase, an enzyme that is highly expressed in most human cancers in which it counteracts telomere shortening–induced senescence to confer cancer cell immortalization. However, the role of PinX1 in telomere regulation, as well as in cancer, is still poorly understood. In this study, we showed that the PinX1 protein is constitutively expressed in… CONTINUE READING
    3 Citations

    Figures and Tables from this paper

    Quantitative analysis of miRNA expression in several developmental stages of human livers
    • 19
    • PDF

    References

    SHOWING 1-10 OF 33 REFERENCES
    The Pin2/TRF1-Interacting Protein PinX1 Is a Potent Telomerase Inhibitor
    • 297
    • Highly Influential
    Human POT1 Facilitates Telomere Elongation by Telomerase
    • 223
    Nucleolar localization of TERT is unrelated to telomerase function in human cells
    • 28
    • PDF
    The POT1–TPP1 telomere complex is a telomerase processivity factor
    • 621
    • PDF
    hEST2, the Putative Human Telomerase Catalytic Subunit Gene, Is Up-Regulated in Tumor Cells and during Immortalization
    • 1,820
    • PDF
    Telomerase Maintains Telomere Structure in Normal Human Cells
    • 725
    Multiple Tumor Suppressor Pathways Negatively Regulate Telomerase
    • 413