Silencing Neurons: Tools, Applications, and Experimental Constraints

  title={Silencing Neurons: Tools, Applications, and Experimental Constraints},
  author={J. Simon Wiegert and Mathias Mahn and Matthias Prigge and Yoav Printz and Ofer Yizhar},
Reversible silencing of neuronal activity is a powerful approach for isolating the roles of specific neuronal populations in circuit dynamics and behavior. In contrast with neuronal excitation, for which the majority of studies have used a limited number of optogenetic and chemogenetic tools, the number of genetically encoded tools used for inhibition of neuronal activity has vastly expanded. Silencing strategies vary widely in their mechanism of action and in their spatial and temporal scales… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 130 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.
11 Citations
199 References
Similar Papers


Publications citing this paper.
Showing 1-10 of 11 extracted citations


Publications referenced by this paper.
Showing 1-10 of 199 references

Optogenetics. Engineering of a light-gated potassium

  • C. Cosentino, L. Alberio, +8 authors J.L
  • 2015
Highly Influential
6 Excerpts

Similar Papers

Loading similar papers…