Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling.

@article{Cao2016SilencingNB,
  title={Silencing NKD2 by Promoter Region Hypermethylation Promotes Esophageal Cancer Progression by Activating Wnt Signaling.},
  author={Baoping Cao and Weili Yang and Yongshuai Jin and Meiying Zhang and Tao He and Qi-min Zhan and James G. Herman and Guanglin Zhong and Mingzhou Guo},
  journal={Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer},
  year={2016},
  volume={11 11},
  pages={
          1912-1926
        }
}
INTRODUCTION Naked cuticle homolog 2 (NKD2) was found to be frequently methylated in human breast and gastric cancers. However, the epigenetic changes and mechanisms of NKD2 in human esophageal cancer remain unclear. METHODS Nine esophageal cancer cell lines and 154 cases of primary esophageal cancer samples were analyzed using methylation-specific polymerase chain reaction, immunohistochemical analysis, Western blot, and xenograft mouse models. RESULTS Loss of NKD2 expression and complete… CONTINUE READING
BETA
3
Twitter Mentions

References

Publications referenced by this paper.
SHOWING 1-10 OF 61 REFERENCES

Similar Papers

Loading similar papers…