Silencing CA3 disrupts temporal coding in the CA1 ensemble

@article{Middleton2016SilencingCD,
  title={Silencing CA3 disrupts temporal coding in the CA1 ensemble},
  author={Steven J Middleton and Thomas J McHugh},
  journal={Nature Neuroscience},
  year={2016},
  volume={19},
  pages={945-951}
}
In addition to the place-cell rate code, hippocampal area CA1 employs a temporal code, both on the single-cell and ensemble level, to accurately represent space. Although there is clear evidence that this precise spike timing is organized by theta and gamma oscillations that are present in hippocampus, the circuit mechanisms underlying these temporal codes remain poorly understood. We found that the loss of CA3 input abolished temporal coding at the ensemble level in CA1 despite the persistence… CONTINUE READING
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