Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER

@inproceedings{Irizar2010SilencedYC,
  title={Silenced yeast chromatin is maintained by Sir2 in preference to permitting histone acetylations for efficient NER},
  author={Agurtzane Irizar and Yachuan Yu and Simon H. Reed and Edward J Louis and Raymond Edward Waters},
  booktitle={Nucleic acids research},
  year={2010}
}
Very little is currently known about how nucleotide excision repair (NER) functions at the ends of chromosomes. To examine this, we introduced the URA3 gene into either transcriptionally active or repressed subtelomeric regions of the yeast genome. This enabled us to examine the repair of ultraviolet (UV)-induced cyclobutane pyrimidine dimers (CPDs) in identical sequences under both circumstances. We found that NER is significantly more efficient in the non-repressed subtelomere than the… CONTINUE READING

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