Silence of the fathers: early X inactivation.

  title={Silence of the fathers: early X inactivation.},
  author={Mimi K Cheng and Christine M Disteche},
  journal={BioEssays : news and reviews in molecular, cellular and developmental biology},
  volume={26 8},
X chromosome inactivation is the mammalian answer to the dilemma of dosage compensation between males and females. The study of this fascinating form of chromosome-wide gene regulation has yielded surprising insights into early development and cellular memory. In the past few months, three papers reported unexpected findings about the paternal X chromosome (X(p)). All three studies agree that the X(p) is imprinted to become inactive earlier than ever suspected during embryonic development… CONTINUE READING