Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum

@inproceedings{Guizetti2013SilenceAP,
  title={Silence, activate, poise and switch! Mechanisms of antigenic variation in Plasmodium falciparum},
  author={Julien Guizetti and Artur Scherf},
  booktitle={Cellular microbiology},
  year={2013}
}
Phenotypic variation in genetically identical malaria parasites is an emerging topic. Although antigenic variation is only part of a more global parasite strategy to create adaptation through epigenetically controlled transcriptional variability, it is the central mechanism enabling immune evasion and promoting pathogenesis. The var gene family is the best-studied example in a wide range of clonally variant gene families in Plasmodium falciparum. It is unique in its strict selection of a single… CONTINUE READING
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