Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children.

@article{Namachivayam2006SildenafilPR,
  title={Sildenafil prevents rebound pulmonary hypertension after withdrawal of nitric oxide in children.},
  author={Poongundran Namachivayam and Ulf Theilen and Warwick Butt and Sian M Cooper and Daniel J. Penny and Lara S. Shekerdemian},
  journal={American journal of respiratory and critical care medicine},
  year={2006},
  volume={174 9},
  pages={1042-7}
}
RATIONALE Rebound pulmonary hypertension (PHT) can complicate the weaning of nitric oxide (NO), and is in part related to transient depletion of intrinsic cyclic guanosine monophosphate. Rebound is characterized by increased pulmonary arterial (PA) pressure, cardiopulmonary instability, and in some cases, the need to continue NO beyond the intended period of use. There is anecdotal evidence that sildenafil, a phosphodiesterase-5 inhibitor, may prevent recurrence of rebound. OBJECTIVES We… CONTINUE READING

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